Bhubaneswar: A few researchers of Melbourne have mapped immune responses from one of Australia’s first novel coronavirus (COVID-19) patients, showing the body’s ability to fight out the virus and recover from infection. Researchers at Peter Doherty Institute for infection and immunity – a joint venture between University of Melbourne and Royal Melbourne hospital – were able to test blood samples at four different time points in an otherwise healthy woman in her early 40s, who presented with COVID-19 and had mild-to-moderate symptoms requiring hospital admission.
A detailed report of how the patient’s immune system responded to the virus, was published in ‘Nature Medicine’ few days back. One of the authors on the paper, research fellow Dr Oanh Nguyen said this was the first time that broad immune responses to COVID-19 have been reported.
“We looked at the whole breadth of the immune response in this patient using the knowledge we have built over many years of looking at immune responses in patients hospitalised with influenza. Three days after the patient was admitted, we saw large populations of several immune cells, which are often a tell-tale sign of recovery during seasonal influenza attack, so we predicted that the patient would recover in three days, which is what happened,” Dr Nguyen revealed.
The team was able conduct the research rapidly thanks to SETREP-ID (Sentinel Travellers and Research Preparedness for Emerging Infectious Disease), led by ‘Royal Melbourne Hospital Infectious Diseases Physician of Indian-origin Dr Irani Thevarajan at Doherty Institute.
SETREP-ID is a platform that enables a broad range of biological sampling to take place in returned travellers in the event of a new and unexpected infectious disease outbreak, which is exactly how COVID-19 started in Australia.
“When COVID-19 emerged, we already had ethics and protocols in place so we could rapidly start looking at the Coronavirus-2 and the immune system in great detail. Already established at a number of Melbourne hospitals, we now plan to roll out SETREP-ID as a national study,” Dr Thevarajan said.
Working together with University of Melbourne Professor Katherine Kedzierska, a laboratory head at the Doherty Institute and a world-leading influenza immunology researcher, the team was able to dissect the immune response leading to successful recovery from COVID-19, which might be the secret to finding an effective vaccine.
“We showed that even though COVID-19 is caused by a new virus, in an otherwise healthy person, a robust immune response across different cell types was associated with clinical recovery, similar to what we see in influenza. This is an incredible step forward in understanding what drives recovery of COVID-19. People can use our methods to understand the immune responses in larger COVID-19 cohorts and also understand what’s lacking in those who have fatal outcomes,” Professor Kedzierska expressed.
Dr Thevarajan added that current estimates show more than 80 per cent of COVID-19 cases are mild-to-moderate, and understanding the immune response in these mild cases is very important research.
“We hope to expand our work now nationally and internationally to understand why some people die from COVID-19, and build further knowledge to assist in the rapid response of this dreaded coronavirus and other viruses to emerge in the future days,” she asserted.
PNN & Agencies